Microdosimetry for Targeted Alpha Therapy of Cancer
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چکیده
منابع مشابه
Microdosimetry for Targeted Alpha Therapy of Cancer
Targeted alpha therapy (TAT) has the advantage of delivering therapeutic doses to individual cancer cells while reducing the dose to normal tissues. TAT applications relate to hematologic malignancies and now extend to solid tumors. Results from several clinical trials have shown efficacy with limited toxicity. However, the dosimetry for the labeled alpha particle is challenging because of the ...
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Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...
متن کاملsystemic targeted alpha radiotherapy for cancer
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ژورنال
عنوان ژورنال: Computational and Mathematical Methods in Medicine
سال: 2012
ISSN: 1748-670X,1748-6718
DOI: 10.1155/2012/153212